| Microorganism name |
Streptomyces sp.
|
| Target proteins |
Alpha-amylase (in S. lividans) (Sevillano et al., 2017)
|
| Wild-type or GMO |
GMO (Sevillano et al., 2017)
|
| Production mode (intracellular/extracellular) |
Extracellular (Sevillano et al., 2017)
|
| Protein yield (g/L or g/g?) |
Not reported in g/L, 1.1 *106 U/L (Sevillano et al., 2017)**
|
| Temperature used in study |
28°C (Sevillano et al., 2017)
|
| pH used in study |
NA |
| C & N source |
Sucrose, yeast extract, xylose (Sevillano et al., 2017)
|
| Regulatory status in Europe |
Not allowed |
| Regulatory status in other parts of the world |
No FDA GRAS approval in US, not allowed in Canada |
| Companies |
NA |
| Publications/references |
-
Sevillano, L., Díaz, M., & Santamaría, R. I. (2017). Development of an antibiotic marker-free platform for heterologous protein production in Streptomyces. Microbial Cell Factories, 16(1). https://doi.org/10.1186/s12934-017-0781-y
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Berini, F., Marinelli, F., & Binda, E. (2020). Streptomycetes: Attractive Hosts for Recombinant Protein Production. Frontiers in Microbiology, 11. https://doi.org/10.3389/fmicb.2020.01958
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Van Wezel, G. P., Krabben, P., Traag, B. A., Keijser, B. J. F., Kerste, R., Vijgenboom, E., Heijnen, J. J., & Kraal, B. (2006). Unlocking Streptomyces spp. for Use as Sustainable Industrial Production Platforms by Morphological Engineering. Applied and Environmental Microbiology, 72(8), 5283–5288. https://doi.org/10.1128/aem.00808-06
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Cuebas‐Irizarry, M. F., & Grunden, A. M. (2023). Streptomyces spp. as biocatalyst sources in pulp and paper and textile industries: Biodegradation, bioconversion and valorization of waste. Microbial Biotechnology, 17(1). https://doi.org/10.1111/1751-7915.14258
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Jennings, S., Craig, S., Bryan, S., & Shivaprasad, P. (2025). Study of the potential for Streptomyces coelicolor to produce bioactive compounds from flower waste as a sustainable feedstock. Sustainable Chemistry for Climate Action, 6, 100084. https://doi.org/10.1016/j.scca.2025.100084
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Dulermo, T., Coze, F., Virolle, M., Méchin, V., Baumberger, S., & Froissard, M. (2015). Bioconversion of agricultural lignocellulosic residues into branched-chain fatty acids usingStreptomyces lividans. OCL, 23(2), A202. https://doi.org/10.1051/ocl/2015052
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Hwang, S., Lee, Y., Kim, J. H., Kim, G., Kim, H., Kim, W., Cho, S., Palsson, B. O., & Cho, B. (2021). Streptomyces as Microbial Chassis for Heterologous Protein Expression. Frontiers in Bioengineering and Biotechnology, 9. https://doi.org/10.3389/fbioe.2021.804295
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Eastham, J. L., & Leman, A. R. (2024). Precision fermentation for food proteins: ingredient innovations, bioprocess considerations, and outlook — a mini-review. Current Opinion in Food Science, 58, 101194. https://doi.org/10.1016/j.cofs.2024.101194
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Gunjal, A., & Bhagat, D. S. (2022). Diversity of actinomycetes in Western Ghats. In Elsevier eBooks (pp. 117–133). https://doi.org/10.1016/b978-0-323-90148-2.00007-9
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